Designated on the National Register in November 2002, the Eastside Historic District is a large, residential neighborhood located east of the Savannah Victorian District. Eastside developed as a series of subdivisions that followed the establishment of streetcar lines by Jacob S. Collins through the area in 1891. By 1898, Collins had laid out lots for the largest development called Collinsville. The streets were laid out by 1900 and most of the land had been subdivided into small residential lots. Most of the streets continue the city’s 19th-century gridiron pattern.

The Seaboard Coast Line runs north through the historic district on the rail bed that was built by the Savannah and Albany Railroad in the middle of the 19th century. A historic plate-girder railroad bridge carries the rail over Henry Street. Both the rail line and the bridge are important elements of the Eastside plan that convey how the neighborhood developed.

The earliest houses reflect the architecture of the adjacent Victorian district with large, two-story frame houses set on small lots in Queen Anne or other late 19th-century eclectic styles. These houses often feature large porches, towers, picturesque rooflines, and intricate details. Eastside also consists of several examples of Neoclassical Revival-style houses, which was popular in Georgia from the 1890s to the 1930s. Some built in the 20th century reflect the Craftsman style. Other less common houses are Second Empire and Italianate styles. Though predominantly residential, the district contains neighborhood commercial buildings and community landmark buildings throughout

The historic district is bounded by Gwinnett, East Broad, Anderson, and Cedar Streets.